A SECRET WEAPON FOR PKRRATING

3B). R526 through the loop in between αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the leading chain carbonyl of R413. The idea of your activation phase is stabilized by a hydrogen bond between Y454 and E480 from αF. dur